Sympathetic Nervous System Pharmacology MCQs

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MCQs and Solution

Q1. Which is NOT an action of Adrenergic system

a) Enhance the cardiac activity

b) Decrease the Digestion

c) Bronchodilation

d) Male penis erection

Ans: d) Male penis erection

 Q2. Which is the neuronal precursor of synthesis of Noradrenaline?

a) Phenylalanine

b) tyrosine

c) tyramine

d) dopamine

Ans:  b) tyrosine

 Q3.  Which is not a catecholamine derivative?

a) Adrenaline

b) Dobutamine

c) Dopamine

d) Amphetamine

Ans: d) Amphetamine

 Q4. Which drug stimulates the Sympathetic neurotransmission:

a) Alfa-Methyl tyrosine

b) Methyldopa

c) Imipramine

d) Reserpine

Ans: C) Imipramine

Neuromodulators:

  • Alfa-Methyl tyrosine & Methyldopa – interfere with synthesis
  • Imipramine – inhibits neuronal uptake
  • Reserpine – inhibits vesicle transport

Q5. Epinephrine decreases intracellular cAMP levels by acting on:

a) α1 receptor

b) α2 receptor

c) beta1 receptor

d) beta2 receptor

 Ans: b) α2 receptor (GiPCR)

  • Alfa 1- GqPCR
  • Beta- GsPCR

Q6. Sympathetic stimulation is mediated by:

a) Release of norepinephrine from nerve terminals

b) Activation of adrenoreceptors on postsynaptic sites

c) Release of epinephrine from the adrenal medulla

d) All of the above

 Ans: d) All of the above

Q7. Beta adrenoreceptor subtypes is contained in all of the following tissues EXCEPT:

a) Bronchial muscles

b) Heart

c) Pupillary dilator muscle

d) Fat cells

 Ans: C) Pupillary dilator muscle

  • Bronchial muscles – Beta 2
  • Heart – Beta 1
  • Pupillary dilator muscle – Alfa 1
  • Fat cells – Bata 3

Q8. In which of the following tissues both alfa and beta adrenergic stimulation produces the same effect?

a) Blood vessels

b) Intestine

c) Uterus

d) Bronchial muscles

 ANS: b) Intestine

  • Blood vessels – alfa1 (Contract) & Beta2 (relax)
  • Intestine – alfa1 (relax) & Beta2 (relax)
  • Uterus – alfa1 (Contract) & Beta2 (relax)
  • Bronchial muscles – alfa1 (Contract) & Beta2 (relax)

Q9. The effects of sympathomimetics on blood pressure are associated with their effects on:

a) The heart

b) The peripheral resistance

c) The venous return

d) All of the above

 Ans: d) All of the Above

  • The heart – B1 (HR)
  • The peripheral resistance – Alfa1 & Beta2
  • The venous return – Beta1 (renin release)

Q10. A nonselective beta receptor agonist causes all of the following effects EXCEPT:

a) Increase cardiac output

b) Increase peripheral arterial resistance

c) Decrease peripheral arterial resistance

d) Decrease the mean pressure

Ans: (b) Increase peripheral arterial resistance

  • Non selective Beta agonist – Isoprenaline
  • B1 R – (+) HR, FC, CO
  • B2 R – (-) TPR and Mean Pressure

Q11. All of the following agents are beta receptor agonists EXCEPT:

a) Epinephrine

b) Isoproterenol

c) Methoxamine

d) Dobutamine

 Ans: c) Methoxamine

Q12. Which of the following direct-acting drugs is a relatively pure alfa agonist, an effective mydriatic and decongestant and can be used to raise blood pressure?

a) Epinephrine

b) Norepinephrine

c) Phenylephrine

d) Ephedrine

 Ans: c) Phenylephrine

 Q13. Hyperglycemia induced by epinephrine is due to:

a) Gluconeogenesis (beta2)

b) Inhibition of insulin secretion (alfa2)

c) Stimulation of glycogenolysis (beta2)

d) All of the above

 Ans: d) All of the above

Q14. Which of the following sympathomimetics is preferable for the treatment of chronic orthostatic hypotension?

a) Epinephrine

b) Norepinephrine

c) Ephedrine

d) Salmeterol

Ans: b) Norepinephrine

Q15. Which of the following sympathomimetics is preferable for the emergency therapy of cardiogenic shock?

a) Norepinephrine

b) Dobutamine

c) Isoproterenol

d) Methoxamine

Ans: b) Dobutamine or Epinephrine

Q16. Indicate the irreversible alfa receptor antagonist:

a) Tolazoline

b) Labetalol

c) Prazosin

d) Phenoxybenzamine

 Ans: d) Phenoxybenzamine

Q17. Nonselective alfa-receptor antagonists are most useful in the treatment of:

a) Asthma

b) Cardiac arrhythmias

c) Pheochromocytoma

d) Chronic hypertension

 Ans: c) Pheochromocytoma

Q18. Indicate an alfa receptor antagonist, which is an efficacious drug in the treatment of mild to moderate systemic hypertension:

a) Phentolamine

b) Tolazoline

c) Ergotamine

d) Prazosin

 Ans: d) Prazosin

Q19. Which of the following beta receptor antagonists is preferable in patients with asthma, diabetes or peripheral vascular diseases?

a) Propranolol

b) Metoprolol

c) Nadolol

d) Timolol

 Ans: b) Metoprolol

Q20. Serious unwanted effect of epinephrine is

a) Respiratory difficulty

b) Palpitation

c) Cerebral heamorrhage

d) Tremor

 Ans: (c) Cerebral heamorrhage

Q21. Following statements are true for Ritodrine

[P] It is β2 agonist

[Q] It produces arrhythmia as side effect

[R] It is β1 agonist

[S] It is used for nasal decongestion

            (a) P and Q                  (b) Q and R

            (c) P and R                  (d) Q and S

 Ans: a) P & Q

Q22. Reflux tachycardia is NOT occurs when………………..is administered

a) Nor-Adrenaline

b) Phenoxybenzene

c) Isoprenaline

d) Prazocine

 Ans: a) Nor adrenaline – Reflux Bradycardia

Q23. Hyperglycemia induced by epinephrine is due to:

a) Gluconeogenesis (beta2)

b) Inhibition of insulin secretion (alfa2)

c) Stimulation of glycogenolysis (beta2)

d) All of the above

Ans: d) All of the above

Q24. Which drug only work on alfa receptor

a) Dobutamine

b) Norepinephrine

c) Phenylephrine

d) Isoprenaline

 Ans: c) Phenylephrine

Q25. Which drug only work on beta receptor Except

a) Dobutamine

b) Salbutamol

c) Ritodrine

d) Albuterol

 Ans: a) Dobutamine

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