Parasympathetic Nervous System MCQs

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MCQs and Solution

Q1. Which is NOT a neurotransmitter of ANS

a) Acetylcholine

b) Adrenaline

c) Nor-epinephrine

d) None

Ans: d) none

 Q2. Which cranial nerve involve in parasympathetic system

a) I

b) III

c) V

d) VIII

 Ans: b) III                                                                          

  • III-oculomotor – eye movement
  • VII – Facial – control lacrimation
  • IX- Glossopharyngeal – Control salivary secretion
  • X- Vegus- – heart, Lungs, Uper GIT and Liver

 Q3. Which is not an action of parasympathetic system

a) inhibition of cardiac activity

b) increase digestion

c) Increase lacrimation

d) expand energy

Ans: d) expand energy

Q4. Which is NOT a symptoms of mushroom poisoning/organophosphate poisoning:

a) Salivation, lacrimation, nausea, vomiting

b) Dryness of mouth, hyperpyrexia, hallucination

c) Headache, abdominal colic

d) Bradycardia, hypotension and shock

Ans: b) Dryness of mouth, hyperpyrexia, hallucination

 Q5.  Which of the following cholinomimetics activates both muscarinic and nicotinic receptors?

a) Carbachol

b) Pilocarpine

c) Nicotine

d) Bethanechol

 Ans: a) Carbachol

  • Ach: MR & NR
  • Methacholine: MR
  • Carbachol: MR & NR
  • Bethanehol: MR

Q6. Which is NOT a Characteristics of pilocarpine

a) It is a tertiary amine alkaloid

b) It causes miosis and a decrease in intraocular pressure

c) Causes a decrease in secretory and motor activity of gut

d) It is useful in the treatment of glaucoma

 Ans: c) Causes a decrease in secretory and motor activity of gut

Q7.   Which Cholinergic responsible for GI secretion

a) M1

b) M2

c) M3

d) Nm

Ans: M1

Q8. The mechanism of action of indirect-acting cholinomimetic agents is:

a) Binding to and activation of muscarinic or nicotinic receptors

b) Inhibition of the hydrolysis of endogenous acetylcholine

c) Stimulation of the action of acetylcholinesterase

d) Releasing acetylcholine from storage sites

 Ans: b) Inhibition of the hydrolysis of endogenous acetylcholine

  • Anticholine esterase/ ChE inhibitors are the indirect acting cholinomimetic agents.
  • They decrease the degradation of Ach by inhibiting ChE enzyme

Q9. Which of the following cholinomimetics is commonly used in the treatment of glaucoma?

a) Pilocarpine

b) Lobeline

c) Acetylcholine

d) Neostigmine

 ANS: a) Pilocarpine

Q10. Indicate the organophosphate cholinesterase inhibitor, which can be made up in an aqueous solution for ophthalmic use and retains its activity within a week:

a) Physostigmine

b) Edrophonium

c) Echothiophate

d) Neostigmine

 

Ans: c) Echothiophate

Q11. Which of the following cholinomimetics is most widely used for paralytic ileus and atony of the urinary bladder?

a) Lobeline

b) Neostigmine

c) Pilocarpine

d) Echothiophate

 Ans: (b) Neostigmine

Q12. Which of the following cholinomimetics is a drug of choice for reversing the effects of nondepolarizing neuromuscular relaxants?

a) Echothiophate

b) Physostigmine

c) Edrophonium

d) Pilocarpine

 Ans: c) Edrophonium or Neostigmine

Q13. Which of the following cholinomimetics is used in the treatment of atropine intoxication?

a) Neostigmine

b) Carbochol

c) Physostigmine

d) Lobeline

 Ans: c) Physostigmine

Q14. Which of the following drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?

a) Atropine

b) Pilocarpine

c) Pralidoxime

d) Edrophonium

 Ans: a) Pralidoxime

  • Acute toxicity- Pralidoxime, a ChE reactivatior
  • Chronic toxicity- Atropine

Q15. Which of the following agents is a ganglion-blocking drug?

a) Homatropine

b) Hexamethonium

c) Rapacuronium

d) Edrophonium

Ans: b) Hexamethonium

Q16. Indicate the skeletal muscle relaxant, which is a depolarizing agent:

a) Vencuronium

b) Scopolamine

c) Succinylcholine

d) Hexamethonium

 Ans: c) Succinylcholine

  • Depolarizing/ Non comp. blocker: Succinylcholine (Nm Agonist)
  • Nondepolarizing/ Competetive blocker: d-Tubocurarin, Atracurium, Vencuronium. These are the Nm Blocker

Q17. Indicate the drug, which is rapidly and fully distributed into CNS and has a greater effect than most other antimuscarinic agents?

a) Atropine

b) Scopolamine

c) Homatropine

d) Ipratropium

 Ans: b) Scopolamine

Q18. Which of the following antimuscarinic drugs is often effective in preventing or reversing vestibular disturbances, especially motion sickness?

a) Atropine

b) Ipratropium

c) Scopolamine

d) Homatropine

Ans: c) Scopolamine

Q19. Which of the following drugs is useful in the treatment of Parkinson′s disease?

a) Benztropine

b) Edrophonium

c) Succinylcholine

d) Hexamethonium

 Ans: a) Benztropine

Q20. Which of the following agents is used as an inhalation drug in asthma?

a) Atropine

b) Ipratropium

c) Lobeline

d) Homatropine

 Ans: b) Ipratropium

Q21. Indicate the ganglion-blocking drug, which can be taken orally for the treatment of hypertension?

a) Mecamylamine

b) Scopolamine

c) Trimethaphane

d) Vecocuronium

 Ans: a) Mecamylamine

  • It is also used for smoking termination along with nicotine in nicotine patches.

Q22. Which of the following neuromuscular blocking agents cause cardiac arrhythmias?

a) Vecuronium

b) Tubocurarine

c) Rapacuronium

d) Succinylcholine

 Ans: d) Succinylcholine

 Q23. Which of the following diseases can augment the neuromuscular blockade produced by nondepolarizing muscle relaxants?

a) Myasthenia gravis

b) Burns

c) Asthma

d) Parkinsonism

 Ans: a) Myasthenia gravis

Q24.  Which is used as mydriatic and cycloplegic action?

a) Homotropine

b) Scopolamine

c) Benztropine

d) Ipratropium

Ans: a)  Homatropine

 Q25. Signal transduction  of Smooth contraction via Ach is

a) activation of cAMP pathway

b) Activation of IP3/DAG pathway

c) Activation of LGIC (Na+ Channel)

d) None

 

Ans: b) Activation of IP3/DAG pathway

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